The team was without four starters -- point guard Mike Conley, center Chris Andersen and forwards Zach Randolph and Matt Barnes -- on Monday when it took on LeBron James and the Eastern Conference's top team. The banged up Grizzlies were already missing franchise center Marc Gasol.
The Grizzlies initially announced that both Conley (foot) and Andersen (shoulder) would sit. About 90 minutes before the opening tip, coach David Joerger said Randolph (knee) and Barnes (hamstring) would also rest.
Joerger said Conley underwent an MRI, and the team hopes to have more information on him and Andersen later this week.
"We'll look at them more at the end of the week," Joerger said. "They are going to be out for a while."
One positive for the Grizzlies was that guard Tony Allen was back after missing eight games with a sore left knee. Allen led the way with a team-high 26 points in a win that left Cleveland's James questioning if his team is ready for the postseason.
Conley is the club's playmaker. He is averaging 15.3 points, 2.9 rebounds and a team-high 6.1 assists in 56 starts this season. Andersen is averaging 3.1 points and 3.2 rebounds in 16 games for both Memphis and Miami.
Randolph averages 14.6 points and 7.9 rebounds, and Barnes averages 9.0 points and 5.1 rebounds.
Joerger said the Grizzlies hope to have an update on Conley and Andersen, who injured his shoulder Sunday in a loss at Phoenix, by Friday. After playing Cleveland, Memphis visits Boston on Wednesday.
The Grizzlies have had a rash of major injuries this season. Gasol is done for the season with a broken right foot, and forward Brandan Wright has been sidelined with a strained right knee.
Information from The Associated Press was used in this report.