He scored eights points and had five assists in 24 minutes off the bench as the Spurs lost 99-94.
Ginobili had missed the last two weeks with a strained oblique and sat out a month before that with a broken hand.
Ginobili was averaging 19.8 points before breaking his hand five games into the season. Yet the Spurs have held up remarkably well without him, sitting just 3½ games behind first-place Oklahoma City entering Sunday night.
Information from The Associated Press was used in this report.