Millsap is sidelined for a second straight game after he was hurt in the first quarter of Utah's 110-107 overtime loss to Boston on Monday. Jefferson was injured in a 102-91 loss to Atlanta on Wednesday.
Both players have missed just two games this season. Jefferson leads the Jazz with 17.7 points and 9.4 rebounds per game. Millsap is right behind him with 15.1 points and 7.3 rebounds per game.
Millsap says he doesn't like to miss games but "you got to know your limitations. You got to know what you can and cannot do."