A day after vowing to be done with Twitter, the outspoken manager of the Miami Marlins continued to shoot from the hip, saying Wade's behavior toward Heat coach Erik Spoelstra during a Thursday loss "can guarantee a fight."
"I will kick (my player's) ass," Guillen told reporters Friday. "Well, I won't say I'll kick his ass. They'll kick my ass because they're bigger than me, and I'm older. But I will take my chances. Some people have to understand our job."
The manager, barely a month removed from a team ban stemming from pro-Fidel Castro comments in which he praised the former Cuban dictator's ability to stay in power, stood in stark contrast to Spoelstra's take on the sideline event.
Spoelstra said confrontations like the one he had with Wade are routine during intense moments in games and practices.
But count Guillen among those who vehemently disagree, at least from a baseball perspective.
"That's disrespectful. Why he's saying it, when he said it, that's none of my business," Guillen said. "But the player come out and say something (like that to me), he will guarantee a fight."
Wade was held scoreless in the first half of Game 3 and finished with just five points and five turnovers in 37 minutes during a 94-75 loss to the Pacers, dropping Miami into a 2-1 series deficit entering Game 4 on Sunday.
Wade's frustration boiled over in the third quarter when he got into a heated exchange with Spoelstra during a timeout. Wade and Spoelstra came face-to-face briefly, and Wade was then restrained by forward Udonis Haslem.
"You know how many players I take out of the game and they go in the back and talk crap about me?" Guillen said.
"I don't care because I'm going to talk crap about them. If I take you out of the game it's for a reason. You think I want to take you out of the game? You think I want to pinch-hit for you? I pinch-hit for you because you suck. There's somebody else I thought was better than you."
Last month, upon returning from the five-game ban, Guillen said he was putting himself on probation, but added winning would help overcome controversial comments made off the field.
"It's probation about growing up and being better, and be careful to not trust too many people," Guillen said. "That was my problem."
Information from ESPN.com's Michael Wallace was used in this report.