22. George Mason's run
Did you pick UConn to win your 2006 bracket? And did you cheer for the Huskies to beat George Mason in the Elite Eight? Of course you didn't. That's why the NCAA tournament is so great: The underdog is more than a nostalgic concept. It is very real, and in George Mason's case, very unlikely. The Patriots were one of the last teams in the NCAA tournament, a little-known mid-major program outside of Virginia (coached by current Miami man Jim Larranaga). But Mason's victory against UConn to reach the '06 Final Four set the stage for runs by Butler and VCU in 2010 and 2011. It's a whole new world.
-- Eamonn Brennan