Calhoun was close with Eileen Fucile, the sister of his wife, Pat. Fucile died Monday after a 12-year battle with breast cancer. Calling hours and a memorial service will be held in Nashua, N.H., Fucile's hometown.
Calhoun also missed Wednesday's practice. Associate head coach George Blaney, who filled in last season for Calhoun when he missed seven games due to a health issue, will run the team in Calhoun's absence.
"We're not worried, we're still going to be under a great coach," freshman Jeremy Lamb said. "It's going to be a different voice, but the same stuff will be said."
Calhoun spoke to the team before leaving for New Hampshire.
"He's got bigger things to worry about," junior Kemba Walker said. "It's not going to affect us at all, anyway. We're just going to play basketball, that's it."
The Huskies (No. 15 ESPN/USA Today, No. 14 AP) will host Marquette (16-11, 7-7 Big East) at the XL Center in Hartford.
The news of Fucile's death comes the day before the NCAA's Committee on Infractions suspended Calhoun for the Huskies' first three Big East games next season. The committee cited Calhoun for failing to create an atmosphere of compliance in connection with the recruitment of former UConn student Nate Miles.
The Huskies (20-6, 8-6) are in a three-way tie with Cincinnati and West Virginia for eighth place in the conference.
Andy Katz is a senior college basketball writer for ESPN.com. Information from The Associated Press was used in this report.