Glenn Bryant added 13 points for Eastern Michigan (7-5). The Eagles scored the first 14 points, finished 33 of 60 from the field and limited the NAIA Saints (4-11) to 17-of-53 shooting.
Ryan Hopson led Siena Heights with 11 points.
Eastern Michigan will return to action Wednesday at Kentucky.
ESPN's Dan Dakich joins The Paul Finebaum Show to discuss the SEC's presence in the NBA Draft.
Ted Kapita was the top-rated recruit from West Virginia in the class of 2015 and recently played at DME Academy in Florida.
With the Suns drafting Tyler Ulis, they now have five guards on their roster who attended Kentucky.