Tyrone Garland added 15 points and Jerrell Wright posted a double-double with 10 points and 11 rebounds for the Explorers (10-3), who are now 2-0 this season against Big 5 foes. La Salle also beat Villanova 77-74 in overtime on Nov. 25.
Leading 17-16, the Explorers launched a 15-2 run, with Garland hitting three 3-pointers and scoring 11 points in the spurt.
La Salle, which led by as many as 24 in the second half, hit 9 of 22 from long range in its final game before starting Atlantic 10 Conference play.
Maryland point guard Melo Trimble, considered a lock to leave the program before struggling in the second half last season, has withdrawn from the NBA draft and will return for his junior season.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.