IUPUI went into halftime with a 31-26 lead.
The Leathernecks (3-6, 0-1 Summit) had just two players in double digits. Forward Jerryck Owens-Murrey scored 14 points, and James Washington chipped in 13.
Western Illinois shot poorly from the field, making just 25 percent (6-of-24) in the second half. That compared with IUPUI's 50 percent (9-of-18) after halftime.
Charles Matthews, who spent his freshman season at Kentucky, has picked Michigan as his transfer school, according to a source.
Chad Ford and Jeff Goodman offer their opinions on the surprises they're expecting at the NBA draft, with Ford believing there will be a lot of trade activity while Goodman thinks people will be surprised by potential draft spot of Marquese Chriss.
Louisville coach Rick Pitino said he doesn't "have time to figure out what" Kentucky coach John Calipari meant in recent comments that appeared to be a jab at the Cardinals' program.