McFarland, a 7-footer from Lovington, Ill., also had three blocked shots. He disrupted Florida State's inside game all night as the Seminole front court was limited to only 10 points.
Wake Forest (15-8, 5-5 Atlantic Coast Conference) hit its first eight 3-pointers and built a 41-20 lead on its way to a 42-26 halftime lead.
Florida State (14-11, 3-7) rallied to within 50-47 before two McFarland layups and a free throw led a 14-2 run that put the Demon Deacons up 64-49.
Gary Clark added a career-high 13 points for Wake Forest, which shot 56 percent for the game while completing its season sweep of the Seminoles.
Florida State's Ryan Reid was ejected in the first half for punching McFarland in the chest several feet behind the play. Reid was not on the Seminole bench in the second half and conference officials will decide whether he can play Saturday at Maryland.