Creighton (12-2, 2-0) led throughout the first half, enjoying up to a 14-point edge before ending the half with a 40-29 advantage.
The Sycamores outscored the Bluejays 13-6 in the first four minutes of the second half to come within four points, 46-42. But in the remaining nine minutes, Creighton outscored Indiana State 20-12 to seal the Bluejays' win.
Creighton shot 48 percent from field-goal range for the game while the Sycamores managed just 32 percent. Creighton was also 9-for-9 from the free-throw line.