Creighton (12-2, 2-0) led throughout the first half, enjoying up to a 14-point edge before ending the half with a 40-29 advantage.
The Sycamores outscored the Bluejays 13-6 in the first four minutes of the second half to come within four points, 46-42. But in the remaining nine minutes, Creighton outscored Indiana State 20-12 to seal the Bluejays' win.
Creighton shot 48 percent from field-goal range for the game while the Sycamores managed just 32 percent. Creighton was also 9-for-9 from the free-throw line.
Mike Brey is looking at former Notre Dame players to fill two assistant jobs that have opened up with the departures of Martin Ingelsby and Anthony Solomon.
Purdue's 2016-17 prospects got a jolt Wednesday when forward Caleb Swanigan announced he will return for his sophomore season.
Clemson's Jaron Blossomgame says he is withdrawing from the NBA draft and returning to school for a final season.