Jeremy Hazell scored 13 points for Seton Hall (14-9, 5-6 Big East), which never trailed in the game. The Pirates have won five straight.
Jordan Theodore added 11 points for Seton Hall, which went on an 8-0 run to boost the score at halftime to 40-24.
DePaul (8-17, 0-12) was never close after the break. Seton Hall held DePaul to 30 percent shooting in the second half on 7-23 shooting from the field. The Blue Demons, who are winless in the Big East, were 2-for-9 from 3-point range.
ESPN's Dan Dakich joins The Paul Finebaum Show to discuss the SEC's presence in the NBA Draft.
Ted Kapita was the top-rated recruit from West Virginia in the class of 2015 and recently played at DME Academy in Florida.
With the Suns drafting Tyler Ulis, they now have five guards on their roster who attended Kentucky.