Crawford, a sophomore guard, had just nine points in Xavier's 71-61 loss Thursday to Marquette.
Ethan Wragge scored 21 points for Creighton (2-3).
Kenny Frease had two baskets and Mark Lyons added a layup to put Xavier (4-1) up 55-42 with 12:43 minutes remaining. Jamel McLean's slam and a 3-pointer by Dante Jackson extended the Musketeers' advantage to 68-49 with 9 1/2 minutes left.
Holloway had nine points, helping Xavier take a 39-31 halftime lead. Wragge had 10 first-half points, including a 3-pointer at the buzzer.