Carlos Strong added 14 points as the America East Conference's top scoring team (69.6 points per game) handed the Hawks (2-13, 0-2) their 11th straight loss.
The Terriers (7-8, 2-1) trailed 17-13 after Hartford's Joel Barkers made a three-point play with 9:53 left in the first half. But Boston University answered with a 12-2 run.
Holland, who had eight points during the spurt, put the Terriers ahead 25-19 on a 3-pointer with 7:09 left until halftime. The Hawks didn't threaten the rest of the way.
Boston University shot 47.8 percent form the field (22 of 46) and 57.6 percent from 3-point range (10 of 21).