Gasser's 21 points off the bench were the second most by a freshman in his debut in school history.
Trant Simpson led the Panthers (0-2) with 14 points.
Leuer hit 3-pointers on three straight possessions as Wisconsin went up 9-0 with Prairie View missing its first five shots. The Panthers recovered from their dismal start to stay in the game and trailed 43-36 early in the second half.
Wisconsin then went on a 21-3 run over the next five minutes to put the game away. Jordan Taylor scored 10 points in the spurt and finished with 20.