With it tied 30-30 at halftime, Wheeless came off the bench to spark the Spartans, who outscored Jacksonville State 40-23 after the break.
After allowing a 52.2-percent shooting performance in the first half (12 of 23), the Norfolk State defense tightened up in the second, limiting the Gamecocks to just 7 of 24 from the field (29.2 percent).
After leading 36-34 early in the second half, Norfolk State (1-1) outscored Jacksonville State 27-11 over a span of 12:22, capped by Kyle O'Quinn's free throws for a 63-45 lead.
Norfolk State led by as many as 21, 70-49, on Wheeless' jumper with 2:53 remaining.
Mississippi State freshman guard Malik Newman will withdraw from the NBA draft, but sources told ESPN he might explore other opportunities besides returning to Mississippi State.
Seton Hall sophomore Isaiah Whitehead will stay in the NBA draft and not return for his junior season.
Washington State's trio of Josh Hawkinson, Conor Clifford and Ike Iroegbu have withdrawn from the NBA draft and will play their senior season with the Cougars.
|Southeast Missouri State||2-14||8||5-24|
|South Carolina State||12-4||1||19-15|
|North Carolina Central||7-9||6||13-19|
|North Carolina A&T||7-9||6||10-22|