The Nittany Lions (8-4, 1-0 Big Ten) snapped a two-game losing streak with their second straight win at Assembly Hall.
Indiana (9-5, 0-1) has lost three straight and saw its nine-game home winning streak end. Verdell Jones had 15 points and freshman Victor Oladipo scored 14 points in his first career start.
Penn State, the worst shooting team in the Big Ten coming into the game, started 7 of 10 from the field and used four straight 3-pointers to build a 25-11 lead midway through the first half.
Indiana chased the rest of the night, finally taking the lead at 48-47 when Maurice Creek put in a layup with 8:46 to go.
But Brooks answered with back-to-back baskets and the Nittany Lions never trailed again.
adidas Men's Indiana Hoosiers Candy Striped Warm-Up Tear Away PantsPrice: $89.99 Shop
The guard prospect was one of the top players at the annual Spiece Run N Slam event.
SMU has signed a second player from Australia, 6-foot-11 forward Harry Froling, to a national letter of intent. The Mustangs previously signed guard Tom Wilson from Australia.
There's nothing to suggest the Jayhawks won't end up atop the Big 12 for a 13th season in a row. But what about a return to the Final Four?