Daniels and Reddic posted career-highs in points and rebounds. Daniels knocked down five 3-pointers en route to a team-high 22 points, while grabbing six boards and two steals. Reddic recorded his first career double-double with 19 points and 10 rebounds.
VCU led 36-37 at halftime but St. Francis fought back to within three, 58-55, with 46 seconds to play thanks to a Umar Shannon 3-pointer.
Daniels hit a 3-pointer of his own on VCU's next possession to secure the victory.
Shannon led all scorers with 26 points, but no other St. Francis player scored over eight points.
The win was the ninth straight home-opening victory for the Rams.
Nike Men's VCU Rams Basketball Practice Black T-ShirtShop
Oklahoma State basketball player Tyrek Coger died after a 40-minute team workout on the football stadium stairs in hot weather, university officials said Friday.
Prospective NCAA championship host cities must identify local anti-discrimination laws in a questionnaire being sent out by the college sports governing body.
The Class of 2017 is full of talented big men, but Richards is getting noticed by more programs during the current evaluation period in Las Vegas.