Wyatt made all 10 of his free throw attempts and Brown made four 3-pointers for the Owls (4-2), who have won 23 straight at the Liacouras Center to set a school record.
The Chippewas (4-3) cut the deficit to 51-37 at halftime on a 12-4 run, and scored the first six points of the second half to make it 51-43. But Temple went on an 8-0 run, capped by Moore's layup to push its lead to 16 points.
Former Kentucky guard Ed Davender, the only Wildcat with at least 1,500 points and 400 assists, has died. He was 49.
Guard Naz Mitrou-Long, whose 2015-16 season ended in December due to hip problems, has been granted a hardship waiver for the coming season, Iowa State said.
As the Sooners look to life without superstar Buddy Hield and his sidekicks, it's clear their unseasoned players will need to grow up fast.