Eric Donald scored 15 points for the NAIA Bobcats (1-12), who played the game as an exhibition.
South Dakota shot 57 percent (38 of 67) and converted 13 of 24 3-point attempts (54 percent).
Trailing 10-9, the Coyotes ran off 10 straight points, including five by Allen Saint-Gelais, for a 19-10 edge with 13:44 to go in the first half.
The lead reached 20 at 38-18 on Steve Tecker's 3-pointer with 6:27 left. South Dakota led 60-32 at halftime.
The Coyotes passed 100 when Boots' 3-pointer made it 101-60 with 2:50 left.
Maryland point guard Melo Trimble, considered a lock to leave the program before struggling in the second half last season, has withdrawn from the NBA draft and will return for his junior season.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.