Josh Swan had 15 points and seven rebounds for the Salukis (4-9, 1-1 Missouri Valley), who never trailed en route to their fourth win in the last five meetings between the schools.
Setty's point total was a season high. The freshman forward started for the first time in six games.
Southern Illinois led 40-32 at intermission and opened the second half with a 19-5 run to take permanent control. Setty had seven points during the surge.
The family of former Houston Astros owner Roy Hofheinz wants a court to require the University of Houston to keep his name on the school's basketball arena.
Michigan has hired assistant basketball coaches Billy Donlon and Saddi Washington.
Duke and Cincinnati, 2016 NCAA tournament teams, highlight the eight-team field for the Naismith Memorial Basketball Hall of Fame Tip-Off Tournament.