Bucknell, who led 38-32 at halftime, opened the second half with nine unanswered to jump ahead 47-32. The Bison never looked back, holding at least a 10 point lead the rest of the way.
The Bison hold the longest conference winning streak in the nation, having won 20 straight games against Patriot League foes dating back to last season.
Rob Delaney led Lafayette (11-14, 6-4) with 22 but fouled out with 3 minutes left to play.
Muscala, Cohen, and Willman all grabbed at least seven rebounds as Bucknell won the battle of the boards 39-22.
ESPN's Dan Dakich joins The Paul Finebaum Show to discuss the SEC's presence in the NBA Draft.
Ted Kapita was the top-rated recruit from West Virginia in the class of 2015 and recently played at DME Academy in Florida.
With the Suns drafting Tyler Ulis, they now have five guards on their roster who attended Kentucky.