The Tigers (14-13, 6-7 Atlantic Coast Conference) have won three of four overall.
The Yellow Jackets, who became the first ACC team with 11 league defeats, have lost 10 of 11 and 14 of 16. Not since losing 40-37 at Boston College on Jan. 19, 1980, had Georgia Tech scored so few points.
Booker opened the second half with a dunk to make it 29-18, and Clemson held a double-digit lead for the rest of the game.
Georgia Tech's offensive output was its lowest in the series since Jan. 25, 1936.