Oklahoma State led 36-22 at halftime and back-to-back field goals by Brown pushed the lead to 50-30 with 12:14 remaining. TCU (9-6, 0-2) got no closer than 14 the rest of the way.
The teams combined for 45 turnovers, 24 by the Cowboys, who broke a two-game losing streak.
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Maryland point guard Melo Trimble has withdrawn from the NBA draft and will return to College Park for his junior season.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.