DeBose added eight rebounds and four steals for the Owls (4-13), who shot 61 percent from the field and were 12 of 24 from 3-point range. Max Guercy had 18 points, six assists and five steals. Rice outscored New Orleans 44-24 in the paint.
Rice never trailed after the opening minutes and led 44-27 at halftime. The Owls kept pouring it on from there, going 20 of 31 from the field in the second half.
The game was only the second meeting between the schools; Rice won the other meeting, 83-49, last season.