Kendrick Perry led the Penguins (13-9, 5-4) with 22 points. Kamren Belin made six 3-pointers and finished with 19 points, and Damian Eargle had 13 points, 12 rebounds and seven blocked shots for Youngstown State.
The game saw 12 lead changes but the Penguins never led by more than two points.
NCAA title game hero Kris Jenkins said he will withdraw his name from the NBA draft and return to Villanova for his senior season.
Andy Katz breaks down the likelihood of Villanova, Syracuse, North Carolina or Oklahoma making a run to the Final Four next season.
Florida State has announced that Xavier Rathan-Mayes will return to the court for his junior season. The 6-foot-4 guard declared for the NBA draft last month but did not hire an agent.