A 3-pointer by Massenat gave the Dragons (11-15, 7-7) a 45-32 lead with 14:15 remaining. The Pride (6-21, 3-11) got it down to five points, 52-47, on Taran Buie's 3-pointer with 7:17 left, but Lee answered with a 3-pointer for Drexel. Layups by Daryl McCoy and Lee made it 59-47.
Stevie Mejia scored 22 points for Hofstra, which lost for the 10th time in 11 games. The senior guard had 14 of his points in the first half, but the Pride went into the break trailing 33-23.
Drexel won this season's first meeting 55-52 on Jan. 23. Buie hit seven 3-pointers for Hofstra to tie a school record, but Massenat's 50-footer at the buzzer won it for the Dragons.