After Elridge Moore's jumper cut Louisiana-Lafayette's deficit to eight, 30-22 with 7:54 left in the first half, Western Kentucky went on a 15-6 run to go up 45-28 with 2:42 left in the period. Price's 3-pointer and Fant's dunk capped the run, and Western Kentucky led at halftime 53-36.
Western Kentucky shot 60.7 percent (17 of 28) in the first half and led by as many as 19 points.
The Hilltoppers led by double digits most of the second half.
Elfrid Payton scored a career-high 31 points for the Ragin' Cajuns (11-18, 7-11).