Zach LeDay added 11 points for the Bulls (12-17, 3-14 Big East), who have won two straight following a 10-game losing streak.
Brock had three baskets and Toarlyn Fitzpatrick made a long-range jumper during an 11-2 surge that gave South Florida a 39-34 lead 5 minutes into the second half. Brock's layup, a 3-pointer by Rudd and a free throw from LeDay made it 47-36 with 10:10 left.
Brock converted a fast-break layup to put the Bulls ahead 53-38. Consecutive slams by Rudd made it 61-44 with 4:07 remaining.
The Huskies took their first lead of the game, at 30-28, on second-half opening baskets by R.J. Evans and Daniels.
Brock had six points to help South Florida take a 28-26 halftime lead.
The Huskies got within 25-24 with 5 minutes to go on a basket and 3-pointer by Daniels, who had 15 first-half points. Connecticut had a chance to tie it in the final minute of the half, but Omar Calhoun missed a wide-open dunk.
Connecticut, behind 24 points by Napier, won the other meeting between the teams this season, 69-64 in overtime on Feb 3.
Connecticut won their other meeting this season, 69-64 in overtime on Feb 3.