Cal Poly (16-12, 11-6 Big West) shot 44.7 percent from the field and was 14 of 20 from the free-throw line while forcing Cal State Fullerton to turn the ball over 15 times.
Kwame Vaughn and Alex Harris scored 22 points apiece and were a perfect 14 of 14 from the line combined for the Titans. Cal State Fullerton (14-16, 6-11) shot 48.8 percent from the field, making 20 of 41 shots including six 3-pointers.
The Mustangs wrap up the No. 3 seed in the Big West Conference tournament and will play sixth-seeded UC Davis on Thursday in Anaheim. Cal State Fullerton drops to the No. 8 seed and will play top seeded Long Beach State.