Loyola won the first meeting of the season behind 25 points by Dylon Cormier, but he did not play in this contest after having surgery on his left hand. The senior was averaging 21.2 points per game and 5.8 rebounds.
Michael Hoffman had nine points and four blocks to lead Lafayette's (7-17, 3-10 Patriot) defensive effort. The Leopards held Loyola to 33 percent, on 16-of-48 shooting, and forced 17 turnovers.
Lafayette led 27-22 at the break and went on a 24-8 run to start the second half. Longwood made two field goals in the first 11 minutes after halftime.