Omaha (16-13, 5-8 Summit League) raced out to 25-11 lead less than 10 minutes into the game, but IUPUI closed the first half with an 11-0 run to head into the break trailing 35-34.
A jumper by Khufu Najee 31 seconds into the second half gave the Jaguars (6-24, 1-12) their first lead but, after trading buckets on the next two possessions for each team, Omaha rattled off 17 consecutive points to open up a 56-40 lead with just more than 12 minutes to play.
The Jaguars never got closer than 14 again, and Omaha led by as many as 27.
Ian Chiles led IUPUI with 20 points.
After a season that saw his shooting numbers slip, should Nigel Hayes return for his senior year at Wisconsin or take the gamble to put him name in this year's NBA draft?
Isaiah Taylor talks about his decision to declare for the NBA draft and what he will miss most about Texas.
Chattanooga women's basketball coach Jim Foster has received a one-year contract extension, the same day the school gave the men's coach a two-year extension.