The Trojans (1-1), who shot 54.9 percent from the field, jumped out to an early 24-8 lead fueled by a layup and a trio of 3-pointers from Williams.
Troy surged further ahead and led by as many as 33 in the first half, coasting to a 59-27 lead at the break.
The Panthers were just 24 of 77 on field goal attempts, struggling to keep pace with the Trojan's shooting performance.
Williams hit five total 3-pointers, grabbed eight rebounds and dished out a game-high five assists. Josh Warren hauled in a game-high 11 rebounds and scored eight points.