Paced by 59.4 percent first-half shooting, Penn State (2-1) led by as many as 25 before coasting into halftime with a commanding 47-24 lead.
Darien Nelson-Henry scored a team-high 21 points for the Quakers (1-2), who pulled within 12 on a pair of Miles Jackson-Cartwright free throws with 11:23 left. But the comeback stalled after Nelson-Henry and Jackson-Cartwright were each whistled for their fourth fouls within 2 minutes of each other midway through the second half.
Newbill and Frazier, who make up one of the nation's best backcourts, never took their foot of the gas, penetrating through the Penn defense at will all afternoon. Frazier finished with a game-high 29 points on 9-for-13 shooting from the field and 11-for-12 shooting from the free-throw line, while Newbill, a Philly native, scored 19 points on 6-for-14 shooting.
Nobody else scored in double figures for the Nittany Lions, who bounced back from a 90-80 home loss to Bucknell on Wednesday.
Fran Dougherty and Tony Hicks both scored 14 points for Penn, which began to use their size advantage to assert some dominance in the paint after the break. But despite the 6-foot-11 Nelson-Henry powering Penn on a quick 10-0 run early in the second half that sliced Penn State's lead to 15 with 17:53 remaining, the Quakers never managed to steal the momentum away from their in-state rivals and get the Palestra crowd back into the game.
For the game, the Quakers shot 20 for 48 from the field and 4 for 19 from 3-point range.
The Nittany Lions came out of the gates on fire, missing only six of their first 19 shots to take a 33-18 lead midway through the first half. They finished the game shooting 29 for 54 from the field and 7 for 20 from 3-point range.
Penn State head coach Patrick Chambers has two older brothers who had standout athletic careers at Penn. Paul Chambers was a three-year starting point guard on Penn from 1989-92 and played one season alongside Penn head coach Jerome Allen. Another brother, Tim Chambers, was the 1984 Ivy League Player of the Year as a defensive back on a Penn football team that won three straight conference titles. . Penn is 47-50 all-time against teams from the Big Ten. The Quakers' next game will also be against a Big Ten opponent as they travel to Iowa on Friday. . Penn State has won eight of its last nine games against Penn, dating back to 1995