The 49ers (11-1) have won two straight since losing to Miami 77-46 on Dec. 14.
Charlotte led 23-6 in the first 10 minutes and 38-19 at halftime as the 49ers shot 56.7 percent from the field (17 of 30) compared to just 26.7 percent (8 of 30) for the Highlanders.
Radford (5-6) got within 12 points twice, at 57-45 with 7:59 remaining and 62-50 with 3:13 to go, but could get no closer.
Chris Braswell, who came in leading the 49ers in scoring (13.4 points a game) and rebounding (6.9), was held to only five points and three boards.
The 49ers, who are 42-8 all-time against Big South Conference teams, outscored the Highlanders 50-28 in the paint.
Javonte Green's 16 points led Radford.
Former Kentucky guard Jamal Murray joins The Paul Finebaum Show to discuss his mindset on the eve of the NBA Draft,
The 2016 NBA draft is just one day away, but it's not too soon to identify future prospects. The next crop of NBA All-Stars will be playing college hoops next season for the nation's top teams.
The University of North Dakota, after dropping its Fighting Sioux nickname four years ago, unveiled the logo for its new Fighting Hawks nickname.
|Texas San Antonio||3-15||13||5-27|