The Panthers (6-11, 1/3 Southwestern Athletic), who ended a six-game losing streak, never trailed after Eleby's jumper gave them an 8-7 lead 4:46 into the game.
Bryant Purvis had 20 points and 11 rebounds for the Tigers (0-14, 0-5), who have lost 24 of their last 25 games dating to last season.
Prairie View A&M led 44-36 when it went on an 11-1 run over the next 3:10 to take permanent control. Blair had nine points during the surge, which ended with his layup that gave the Panthers a 55-37 cushion with 4:06 remaining.
Former Kentucky guard Ed Davender, the only Wildcat with at least 1,500 points and 400 assists, has died. He was 49.
Guard Naz Mitrou-Long, whose 2015-16 season ended in December due to hip problems, has been granted a hardship waiver for the coming season, Iowa State said.
As the Sooners look to life without superstar Buddy Hield and his sidekicks, it's clear their unseasoned players will need to grow up fast.