The Raiders (10-17, 4-6), who snapped a three-game losing streak, led 38-16 with 4:04 left in the half.
Gabe Knutson and Anthony D'Orazio scored 17 points apiece and Holden Greiner had 12 for the Mountain Hawks (18-6, 8-2), whose four-game winning streak was halted. Lehigh was tied with Bucknell atop the Patriot League at 8-1, but Bucknell also lost, falling to Lafayette 63-62.
Colgate shot 38.1 percent on 3-pointers (8 of 21) to Lehigh's 16.7 percent (3 of 18), beat the Mountaineers on the boards 40-33, and the Raiders' bench outscored Lehigh's 15-2.
Lehigh tied Colgate at 56-all on a 3-pointer by D'Orazio with 3:04 left, but James Brandon made two free throws at 1:53, and Lehigh never caught up.
Officials: North Carolina must show proof of discrimination-free zone, or lose NCAA tournament games
North Carolina must prove to the NCAA that its host arenas will provide a discrimination-free zone, or risk losing NCAA tournament games in 2017 and 2018, multiple officials told ESPN.
Jalen Rose and David Jacoby examine the new NCAA draft rule and consider how it would have affected "The Fab Five."
Florida and Duke will meet on Dec. 6 in the Jimmy V Classic at Madison Square Garden as one of two high-profile games to help raise funds for cancer research.