Spiller was stopped on the 25-yard line on the first kickoff Saturday, but the Gamecocks were called for offsides. He took the second kick and cut left for the score to give Clemson (No. 18 BCS; No. 15 AP) the early lead.
Spiller's mark surpasses the six of Southern California's Anthony Davis and Tulsa's Ashlan Davis.
The return also moved Spiller past 7,000 all-purpose yards, the fifth player in NCAA history with that many.
Information from The Associated Press was used in this report.