Purdue starting quarterback Robert Marve will undergo an MRI on Monday to determine the extent of the left knee injury he suffered in Saturday's loss to Toledo.
Coach Danny Hope told reporters on Sunday that the "early prognosis is not encouraging" on Marve, who sustained the injury in the first quarter.
The junior quarterback tore the ACL in his left knee last summer and reinjured it Sept. 18 against Ball State before returning to start against Toledo.
"Right now, I'm assuming he's going to be out for a while," Hope said.
Redshirt freshman Rob Henry took over at quarterback following Marve's injury Saturday. Purdue has a bye week before resuming play Oct. 9 at Northwestern.
Adam Rittenberg covers Big Ten football for ESPN.com. He can be reached at firstname.lastname@example.org.