Ball State led 13-0 early in the second quarter as Scott Secor kicked two field goals and Mann found Mabon for a 34-yard score in between.
Edwards added some cushion for the Cardinals with a 4-yard score in the third quarter.
Mann finished 20 of 32 for 203 yards with an interception.
Colgate converted just 2 of 13 third downs while John Quazza had six catches for 92 yards.
With starting quarterback Thomas Sirk out indefinitely with a torn Achilles, Duke will turn to Parker Boehme to lead the offense.
Kentucky will have to replace five starters on defense in 2016, and its deep recruiting class should help address the need.
A group of transfer quarterbacks and the top wide receiver recruit in the country are among those who could emerge to make a big impact in the Pac-12.
Now is the perfect time to take a closer look at the strength and weakness of each Big 12 team after signing day, beginning with Baylor.
With signing day behind us, here's an early look at how teams stack up in the Pac-12 heading into next season.
The Spartans went into signing day needing to get stronger at receiver, and they did just that, signing four wideouts including two in the ESPN 300.