Ross Jenkins threw for 97 yards and a touchdown as the Bulldogs (5-4, 3-2 WAC) recorded their first shutout in over 12 years.
Duke Ihenacho recorded 11 tackles and Carl Ihenacho had eight as the Spartans (6-4, 4-2 WAC) lost their second straight home game.
The Bulldogs intercepted two passes, leading to a pair of touchdowns, within 1:30 of the second quarter to open a 14-0 lead.
San Jose State quarterback Myles Eden, starting in place of Kyle Reed, was 3-of-8 with the two picks, for 11 yards before Reed, who was nursing a back injury, replaced him. Reed finished 4-of-14 for 79 yards, 62 coming on one play.
The Bulldogs' Weldon Brown intercepted a pass at the Spartans' 21-yard line. On the next play, Jackson ran for the 21-yard touchdown. Less than two minutes later, Terry Carter returned an interception 50 yards for a score.
San Jose State never really threatened in the contest, recording a season-low six first downs and 148 yards of total offense. The Spartans' best chance was a first-and-goal situation early in the fourth quarter. The Spartans lost yardage and threw incomplete on a fourth down play.
Dustin Mitchell caught a 35-yard pass from Jenkins in the fourth quarter to complete the scoring for the Bulldogs, who have won three of their last four games.
Louisiana Tech had scored a total of 24 points in its four previous road games. It could have been worse as the Bulldogs had a kickoff return for a touchdown called back because of a penalty and a punt return for a touchdown called back, also because of a penalty.
Tyler Barnes will rejoin father-in-law Kirk Ferentz's staff at Iowa, this time as the team's new director of recruiting.
The Ducks will sport two different uniforms, both honoring the 100th anniversary of Oregon's first Rose Bowl team, in their spring scrimmage Saturday.
Prosecutors will not appeal a ruling that threw out some of the most serious criminal charges against three former Penn State administrators related to the Jerry Sandusky scandal.
Tim Brando of Fox Sports joins The Paul Finebaum Show to discuss the future of the Ole Miss football program.
There's a reason the Cowboys drafted Ezekiel Elliott No. 4 overall.
SEC Commissioner Greg Sankey joins The Paul Finebaum Show to reflect on the NCAA decision to overturn the satellite camp ban.