The Golden Eagles (5-6, 3-4 Conference USA) won their third consecutive game and ended East Carolina's three-game winning streak. Southern Miss, which lost five straight games earlier this season, needs a win over Southern Methodist in its final regular season game on Nov. 29 to become bowl eligible.
The Pirates (6-4, 4-2) also failed to clinch at least a share of the Conference USA East title and their first trip to the league title game.
Damion Fletcher, Southern Miss' all-time leading rusher, ran for 121 yards on 23 carries and one touchdown in his first game after missing two games with a hamstring injury.
Davis hit Brown one play after Justin Wilson picked off a pass deep in Golden Eagles territory. The scoring play gave Southern Miss a 21-3 lead with 11:37 to play.
Southern Miss took a 7-3 lead into halftime on Davis' 20-yard touchdown pass to Leroy Banks with 4:35 left in the second quarter.
East Carolina took a 3-0 lead early in the quarter on Ben Hartman's 32-yard field goal. Hartman also missed a pair of field goals in the first half.
Davis was 18 of 30 for 239 yards and two scores. Brown had eight catches for 124 yards and needs just three more receptions to tie the school's single season record of 66.
Wilson picked off another pass late in the game to end any hopes of a comeback. East Carolina's Patrick Pickney had thrown just three interceptions in the first nine games.
Dolphins first-round draft pick Laremy Tunsil said he took money from a coach while he was a player at Ole Miss.
SEC Network's Peter Burns and Marcus Spears sit down with Mississippi State coach Dan Mullen to discuss the Bulldogs mindset for the upcoming season.
Crimson Tide defensive line coach Bo Davis is leaving the school amid NCAA and school inquiries over potential recruiting violations, The Tuscaloosa News has reported.
SEC Network's Paul Finebaum discusses the Big 10's celebration after the satellite camp ban was lifted but the SEC is still dominant.
Nick Saban does a live interview with SportsCenter prior to the NFL draft in his car. He discusses the Alabama players in the draft tonight and how he will spend his time at the draft
Former Ohio State running back Ezekiel Elliott wears a cut off shirt on the red carpet, reminiscent of the way he wore his jersey with the Buckeyes in the 2014 season.