The Bulldogs (1-0) jumped to a 14-0 lead Sunday behind two touchdown passes from Long and never trailed at the 2009 MEAC-SWAC challenge in Orlando. But South Carolina State needed an interception from Semaj Moody in the final minute to stop a late rally by Grambling (0-1).
Wiley, who replaced Long in the first half after he went down with cramps, made his impact in the second half. He had a 39-yard run on a designed quarterback draw to set up a short touchdown run by Travil Johnson, giving the Bulldogs a 28-17 lead.
Grambling quarterback Greg Dillon threw for 268 yards and two touchdowns but also lost two fumbles.