The Blue Devils (2-2) surpassed their previous scoring average of 18.3 points per game with 21 in the first quarter, when Thompson rushed for both of his touchdowns.
Quarterback Sean Renfree completed 21 of 30 passes for 278 yards and a touchdown for the Blue Devils. His 7-yard scramble late in the third quarter gave Duke a 45-13 lead.
Duke outgained the Green Wave (2-2) 336 yards to 127 in the first half. The only touchdown until the fourth quarter for Tulane, which scored 49 points last week in a win over UAB, came on Ryan Travis' 23-yard interception return in the first quarter.
Duke's defense, which shut out Boston College in the second half of a 20-19 win last week, had put together a streak of five quarters without allowing a touchdown.
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Daryl Gross, who spent a decade as Syracuse's athletic director, will start as Division II Cal State-Los Angeles' AD in July.
Freshman DB Chad Clay didn't last long with the Georgia football team, as the Bulldogs dismissed him following a second arrest in the past four months.
Brenda Tracy, who allegedly was sexually assaulted by four men, including two Oregon State players, in 1998 spoke Wednesday to the Nebraska football team.
A man who claims he told Penn State football coach Joe Paterno in 1976 that he was sexually abused as a teen by Jerry Sandusky asked a judge Wednesday to protect his identity and limit questions.
FOX Sports' Bruce Feldman joins The Paul Finebaum Show to share his thoughts on the upcoming National Championship race.
Urban Meyer, Thad Matta and Ohio State athletic director Gene Smith were among the crowd at the parade for the Cleveland Cavliers on Wednesday.