OXFORD, Miss. -- LSU's domination of Mississippi was so complete that with more than five minutes remaining in the game, the Tigers lined up in a victory formation, content to kneel four straight times rather than try for another touchdown.
It was the only mercy No. 1 LSU would show during the 52-3 rout Saturday night.
"Victory was assured," LSU coach Les Miles said. "There was no reason to take snaps at that point."
Actually, the Tigers had the win in hand much sooner.
Ron Brooks returned an interception for a touchdown 28 seconds into the game, LSU built a 35-3 lead by halftime and kept pounding away at the Ole Miss defense all night, rushing for 353 yards.
LSU running back Michael Ford said Brooks' big play was all the Tigers needed.
"It definitely took their breath away because it took our breath away, too," Ford said.
The Tigers (11-0, 7-0 Southeastern Conference) matched their best start since 1958. It was the worst margin of defeat for Ole Miss since a 49-0 loss to Georgia in 1974.
Quarterback Jordan Jefferson started his second consecutive game, completing 7 of 7 passes for 88 yards and a touchdown. Alfred Blue led the Tigers with 74 rushing yards while Spencer Ware added 70 yards and a touchdown.
Ole Miss (2-9, 0-7) has lost six straight games and a school-record 13 straight conference games. Barry Brunetti rushed for a team-high 74 yards as the Rebels managed just 195 total yards.
LSU completed all eight of its pass attempts -- seven by Jefferson and one by Jarrett Lee -- but was content to run the ball for most of the game after building a 21-0 lead with 5:11 remaining in the first quarter.
Kenny Hilliard rushed for 59 yards and a touchdown and Terrence Magee added 55 yards as LSU emptied its bench early and recovered from a lackluster effort in last week's 42-9 win against Western Kentucky. Seven different players rushed for at least 25 yards and the Tigers averaged nearly eight yards per play.
Miles was almost apologetic postgame.
"It's unfortunate to have a coach (Houston Nutt) end a home stand in a fashion like today," Miles said. "That being said, we look forward to our future. It's something that we're really pointed to. It's a short week, but we're looking forward to taking on a very talented Arkansas team (next weekend)."
LSU hosts No. 6 Arkansas on Friday in the regular-season finale for both teams.
Ole Miss continued a miserable season that seems to find a new low each week.
The already outmanned Rebels were further crippled when Nutt suspended starting quarterback Randall Mackey and leading rusher Jeff Scott for violating team rules. Without them, the game turned ugly in a hurry.
Ole Miss started with the ball, and its first three plays were a disaster. Starting quarterback Zack Stoudt bounced an incompletion on the first play, Brandon Bolden dropped the next pass and then Stoudt threw a wild lob on a screen pass that was picked off by Brooks and returned 46 yards for a touchdown.
"You can't start the game the way we started, especially with a team like that," Nutt said. "The No. 1 team in the nation, you can't give them gifts. One thing we didn't want to do was turnovers, especially when they get seven points off the bat. That was the worst thing that could happen. They're a really good football team. They're a good football team, but we helped them."
It never improved for the Rebels, who are 0-2 since it was announced on Nov. 7 that Nutt would not return for a fifth season. Nutt agreed to stay for the remainder of the season, and now Ole Miss must win next week's game against Mississippi State to avoid its first 10-loss season in program history.
The Rebels' lone score came on a 39-yard field goal by Bryson Rose, which was set up by Brunetti's 47-yard run.
Ohio State remained No. 1 in the AP Top 25 and tied a poll record Sunday despite lagging support from voters. Meanwhile, No. 2 TCU and No. 3 Baylor edged forward and No. 4 Michigan State slipped.
Will Grier threw four touchdown passes to four receivers -- all in the first half -- and No. 25 Florida downed third-ranked Mississippi 38-10 on Saturday night.
Leonard Fournette highlighted his SEC-record third straight 200-yard game with a 75-yard touchdown run, and No. 9 LSU overcame Eastern Michigan 44-22 on Saturday night.
An officiating error led to an Oklahoma State touchdown Saturday in the Cowboys' 36-34 win over Kansas State.
Texas A&M receiver Ricky Seals-Jones, who was ejected for targeting midway in the second quarter of Saturday's game, took to Twitter late in the game, retweeting a tweet that questioned the call.
As if things weren't going bad enough at Texas, the Longhorns appear to have players on Twitter during lopsided losses and jabs at their coach accidentally being sent from other nearby teams.