The decisive drive went 80 yards in 11 plays and took 2:46 off the clock.
Erik Lora caught 11 passes for 128 yards for Eastern Illinois (4-3, 3-1 Ohio Valley). Garoppolo completed 26 of 51 passes for 220 yards with a pair of interceptions. Jake Walker rushed for 103 yards and a touchdown.
Washaun Ealey had a big day for Jacksonville State (3-3, 2-2), rushing for 149 yards and three TDs.
The Eastern Illinois defense came up with three interceptions of Jacksonville State's Marques Ivory.