Pruneau opened the scoring for the Crimson (5-0) with a 2-yard pass to Cameron Brate in the first quarter. Stanton Jr. ran for a 3-yard touchdown in both the second and third quarters.
Pruneau tossed two more touchdowns in the fourth quarter, a 50-yard strike to Andrew Fischer and a 15-yard score to Brate.
Stanton Jr. had 21 rushes for 113 yards.
Pruneau went 17-of-29 for 263 yards, with 103 of those going to Ricky Zorn.
Reed, who relieved Andrew Dzurik in the second half, was 17-for-22 with 235 yards and an interception for Lafayette.
When there are rules that aren't well known until they're invoked, it can confuse fans, players and even refs. Here's a look of 10 obscure rules in a variety of sports you might not know about.
Ole Miss head coach Hugh Freeze joins The Paul Finebaum Show to share how important the Egg Bowl is to the state of Mississippi.
Former Auburn RB Bo Jackson joins The Paul Finebaum Show to discuss how Auburn can keep up with Alabama in the Iron Bowl.
ESPN senior college football writer Mark Schlabach joins College Football Daily: The Experts to describe the current situation surrounding LSU coach Les Miles and whether or not he will be fired.
Alabama's Derrick Henry and Stanford's Christian McCaffrey are up for both the Maxwell Award and the Doak Walker Award, as finalists for the College Football Awards were announced.