Pruneau opened the scoring for the Crimson (5-0) with a 2-yard pass to Cameron Brate in the first quarter. Stanton Jr. ran for a 3-yard touchdown in both the second and third quarters.
Pruneau tossed two more touchdowns in the fourth quarter, a 50-yard strike to Andrew Fischer and a 15-yard score to Brate.
Stanton Jr. had 21 rushes for 113 yards.
Pruneau went 17-of-29 for 263 yards, with 103 of those going to Ricky Zorn.
Reed, who relieved Andrew Dzurik in the second half, was 17-for-22 with 235 yards and an interception for Lafayette.
During Valentine's Day, relive the worst heartbreaking moments sports teams put their fans through in 2015, including Michigan's debacle over Michigan State and a costly error from the Mets in the World Series.
A lawsuit claiming that the University of Tennessee has violated Title IX policies and created a "hostile sexual environment" includes an alleged incident involving former Vols QB Peyton Manning.
LSU added to its future running back group by picking up a commitment from the playmaking Edwards-Helaire.
Check out the final seconds of Duke's win over Virginia, with the Cavaliers' Malcolm Brogdon scoring a go-ahead layup, followed by Grayson Allen driving to the other end to score an off-balance bucket at the buzzer.
John Lattner, the 1953 Heisman Trophy winner who helped lead Notre Dame to a 9-0-1 record and a No. 2 ranking in Frank Leahy's final year as coach, has died. He was 83.
Jabbar Juluke, the former running backs coach at Louisiana Tech who spent just one month at Texas Tech, will assume the same role on Les Miles' staff at LSU.