Pruneau opened the scoring for the Crimson (5-0) with a 2-yard pass to Cameron Brate in the first quarter. Stanton Jr. ran for a 3-yard touchdown in both the second and third quarters.
Pruneau tossed two more touchdowns in the fourth quarter, a 50-yard strike to Andrew Fischer and a 15-yard score to Brate.
Stanton Jr. had 21 rushes for 113 yards.
Pruneau went 17-of-29 for 263 yards, with 103 of those going to Ricky Zorn.
Reed, who relieved Andrew Dzurik in the second half, was 17-for-22 with 235 yards and an interception for Lafayette.
Linebacker Myles Jack, who suffered a season-ending knee injury, said Thursday he decided to leave UCLA and enter the 2016 NFL draft because he wants to be compensated for his skills.
Randy Edsall will coach Maryland against No. 1 Ohio State on Saturday, the school announced Thursday as rumors swirled about his job status going forward.
Tennessee chancellor Jimmy G. Cheek has issued a statement amid rumors that alleges coach Butch Jones fought and punched senior offensive lineman Mack Crowder during a fall practice session.
With the addition of a few tweaks, UConn football coach Bob Diaco is still planning to bring a rivalry trophy with him to Florida on Saturday when the Huskies play UCF.
Arizona quarterback Anu Solomon will start against Oregon State on Saturday, a source told ESPN.
Rutgers receiver Leonte Carroo returned to practice Thursday after charges that he attacked a woman he used to date were dropped, and he said he was "lucky" to be playing again.