Landers threw for 163 yards and one touchdown and ran for 129 yards and another score.
Noble rushed for 55 yards on 9 carries, including scoring runs of 11 and one. Sullivan gained 28 yards on seven carries, with scoring runs of five and four.
William Richardson went 15-for-25 and threw for 109 yards and one touchdown for the Chanticleers (1-3). Jerome Simpson caught four passes for 39 yards, including a six-yard touchdown.
James Madison ran 232 yards to Coastal Carolina's 47.