San Diego State (3-5, 2-2 Mountain West) got a 27-yard punt return from Brent Swain to start the Aztecs' winning drive at the Wyoming 38-yard line. O'Connell found Brown for the winning score on third-and-13 at the 1:06 mark that put the Aztecs ahead for the first time in the game.
Karsten Sween threw two first-half touchdown passes to Michael Ford for Wyoming (6-3, 3-2), which led 21-0 in the second quarter. Sandwiched in between Sween's TD passes of 19 and 30 yards to Ford was Quincy Rogers' 80-yard interception return for a touchdown late in the first quarter.
The Aztecs, who cut the halftime lead to 21-7 on O'Connell's 13-yard scoring pass to Chaz Schilens with 13 seconds left, scored a pair of touchdowns in less than five minutes in the third quarter to pull to within one, 21-20.
O'Connell ran 29 yards for a TD to trim Wyoming's lead to 21-13 midway through the third quarter. O'Connell, who already holds the school record for career rushing yards by a quarterback, broke the career mark for rushing touchdowns by a quarterback with 15.
After San Diego State's extra point attempt was blocked following O'Connell's touchdown, Brandon Sullivan scored from 29 yards out at the 2:57 mark to narrow Wyoming's lead to 21-20. Billy Vinnedge put Wyoming up 24-20 with a 44-yard field goal with 11:38 to go in the game.
O'Connell finished 20-of-44 passing for 249 yards.
ESPN 300 running back Elijah Holyfield, the son of former heavyweight boxing champion Evander Holyfield, has decided to stay home and attend Georgia, he announced Friday.
Arizona star linebacker Scooby Wright will have an MRI after injuring his left knee in the first quarter of the Wildcats' season-opening 42-32 win over UTSA on Thursday night.
Miami reserve linebacker Al-Quadin Muhammad has been suspended for the season opener against Bethune-Cookman on Saturday for a violation of team rules, a source confirmed to ESPN.com
All-American defensive end Shawn Oakman and safety Orion Stewart have been suspended for Baylor's season opener Friday against SMU for a violation of team rules, a school spokesman told ESPN.com.
Trevone Boykin threw for 246 yards and a touchdown and ran for 92 yards and another score to help No. 2 TCU outlast Minnesota 23-17 on Thursday night.
Ohio State quarterback Cardale Jones is "doing fine" after he was released from the hospital Wednesday night after being treated for symptoms related to a migraine headache.