Ball State (3-0, 1-0 Mid-American Conference) piled up 491 yards of offense.
Chris Jacquemain hit on 21-of-44 passes for 269 yards and a 13-yard scoring pass to Andre Jones, but was also picked off four times -- three of them by Sean Baker. Akron (1-2, 0-1) also lost a fumble.
With the score tied at 10 early in the second quarter, the Cardinals ran off the next 21 points on Lewis' two touchdown runs sandwiched around Baker's 33-yard return of a fumble.
Ball State's Ian McGarvey added field goals of 31 and 32 yards.
Deryn Bowser had eight catches for 117 yards for the Zips.
Corey Robinson is returning for his senior year on the gridiron at Notre Dame while also assuming the responsibilities of student-body president.
Baylor will hire more counselors and provide additional training for faculty in an effort to improve the school's response to sexual assault incidents, school regents said Friday.
Answering questions about the hype around two young quarterbacks, whether Stanford will sooner or later fall back into mediocrity and more.
FOX Sports' Clay Travis joins The Paul Finebaum Show to discuss the possibility of losing Tigers football to budget cuts.
The Naismith Memorial Basketball Hall of Fame announced 14 finalists for the Class of 2016 on Friday, including Allen Iverson, Tom Izzo, Shaquille O'Neal and Yao Ming.
Discussing the transfer of Barry J. Sanders to Oklahoma State, what the latest staff movement means for Charlie Strong and TCU's linebacking corps.